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Over the past two decades the benefits of label-free biosensor analysis have begun to make an impact in the market, and systems are beginning to be used as mainstream research tools in many drug discovery laboratories. Label-Free Technologies For Drug Discovery summarises the latest and emerging developments in label-free detection systems, their underlying technology principles and end-user case studies that reveal the power and limitations of label-free in all areas of drug discovery. Label-free technologies discussed include SPR, NMR, high-throughput mass spectrometry, resonant waveguide plate-based screening, transmitted-light imaging, isothermal titration calorimetry, optical and impedance cell-based assays and other biophysical methods. The technologies are discussed in relation to their use as screening technologies, high-content technologies, hit finding and hit validation strategies, mode of action and ADME/T, access to difficult target classes, cell-based receptor/ligand interactions particularly orphan receptors, and antibody and small molecule affinity and kinetic analysis. Label-Free Technologies For Drug Discovery is an essential guide to this emerging class of tools for researchers in drug discovery and development, particularly high-throughput screening and compound profiling teams, medicinal chemists, structural biologists, assay developers, ADME/T specialists, and others interested in biomolecular interaction analysis.

A Case Approach To Perioperative Drug-drug Interactions PDF Gratis 2019

The occurrence of deleterious or even fatal drug-drug interactions (DDIs) in the perioperative period is no longer a theoretical concern but a harrowing reality. A Case...

Como Descargar Libros Gratis Manufacturing Systems: An Introduction To The Technologies

Intented as a `primer' in manufacturing systems, this book concentrates primarily on the technology that is applied on the shop floor to automate the manufacturing process....

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The 333 design classics featured in this volume show the impact of new technology on design. With the world at our fingertips, thanks to commercial air travel, the colour...

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In contrast to traditional combustion, gasification technologies offer the potential for converting coal and low or negative-value feedstocks, such as petroleum coke and...

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This open access book is written by world-recognized experts in the fields of applied superconductivity and superconducting accelerator magnet technologies. It provides a...

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A song about the life of Marie Curie and her contributions to modern science. Includes online music access.

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